Ingredient guide

Dong Quai (Angelica Sinensis): Menopause Evidence

Dong quai is a traditional Chinese herb often called female ginseng, used for menopausal symptoms. Human evidence is limited and mixed. It has weak estrogen-like activity in laboratory studies, so it is best avoided with hormone-sensitive conditions.

Limited evidence

Benefits

  • Long traditional Chinese medicine use for menstrual and menopausal symptoms.
  • Some serotonin-receptor activity in laboratory studies.
  • One placebo-controlled trial reported a reduction in hot flashes and sleep symptoms.

Evidence summary

What dong quai is

Dong quai is the dried root of Angelica sinensis, a relative of celery and parsley. It has been a centrepiece herb of traditional Chinese medicine for over a thousand years, often called female ginseng and used for menstrual and menopausal symptoms.

What the human research shows

Modern human research is limited and mixed. One small placebo-controlled trial in 55 postmenopausal women reported a significant reduction in hot flushes, sleep disturbances, and fatigue. A trial of dong quai for hot flushes in men on androgen deprivation therapy showed no difference from placebo. Laboratory work shows weak estrogen-like activity, which makes hormone-sensitive conditions a real caution. We grade the evidence as limited.

Dosage & safety

Dosage

There is no firmly established dose. Traditional and trial use ranges from a few grams of dried root in a decoction to 200 mg to 600 mg of standardised extract per day. Ask your healthcare provider before use, especially if you have a hormone-sensitive condition or take blood-thinning medicine.

Side effects

  • Most common are mild stomach upset and sun sensitivity.
  • May increase bleeding risk at higher doses.
  • Skin reactions can occur when used with sun exposure.

Interactions

  • Dong quai may add to the effect of blood-thinning medicine.
  • It may interact with hormone therapy because of its weak estrogen-like activity.

Warnings

  • Speak with a doctor before dong quai use if you have a hormone-sensitive condition, take blood-thinning medicine, or are pregnant.
  • Use sunscreen when starting, since dong quai can increase sun sensitivity.
  • Tell your provider you take it before any planned surgery.

Products with this ingredient

Related ingredient guides

Citations

  1. Can dong quai help with menopause? healthline.com
  2. Botanical modulation of menopausal symptoms: mechanisms of action pmc.ncbi.nlm.nih.gov

Frequently asked questions

Does dong quai help menopause?

Evidence is limited and mixed. One small trial reported benefits, others did not. It is best discussed with a healthcare provider rather than self-prescribed.

Is dong quai safe with hormone-sensitive conditions?

Probably not. Laboratory studies show weak estrogen-like activity, which makes it a poor fit for conditions like estrogen-receptor positive breast cancer.