Ingredient guide

Dong Quai (Angelica Sinensis): Menopause Evidence

Dong quai is a traditional Chinese herb often called female ginseng, used for menopausal symptoms. Human evidence is limited and mixed. It has weak estrogen-like activity in laboratory studies, so it is best avoided with hormone-sensitive conditions.

Limited evidence

Benefits

  • Long traditional Chinese medicine use for menstrual and menopausal symptoms.
  • Some serotonin-receptor activity in laboratory studies.
  • One placebo-controlled trial reported a reduction in hot flashes and sleep symptoms.

Evidence summary

What dong quai is

Dong quai is the dried root of Angelica sinensis, a relative of celery and parsley. It has been a centrepiece herb of traditional Chinese medicine for over a thousand years, often called female ginseng and used for menstrual and menopausal symptoms.

What the human research shows

Modern human research is limited and mixed. One small placebo-controlled trial in 55 postmenopausal women reported a significant reduction in hot flushes, sleep disturbances, and fatigue. A trial of dong quai for hot flushes in men on androgen deprivation therapy showed no difference from placebo. Laboratory work shows weak estrogen-like activity, which makes hormone-sensitive conditions a real caution. We grade the evidence as limited.

Dosage & safety

Dosage

There is no firmly established dose. Traditional and trial use ranges from a few grams of dried root in a decoction to 200 mg to 600 mg of standardised extract per day. Ask your healthcare provider before use, especially if you have a hormone-sensitive condition or take blood-thinning medicine.

Side effects

  • Most common are mild stomach upset and sun sensitivity.
  • May increase bleeding risk at higher doses.
  • Skin reactions can occur when used with sun exposure.

Interactions

  • Dong quai may add to the effect of blood-thinning medicine.
  • It may interact with hormone therapy because of its weak estrogen-like activity.

Warnings

  • Speak with a doctor before dong quai use if you have a hormone-sensitive condition, take blood-thinning medicine, or are pregnant.
  • Use sunscreen when starting, since dong quai can increase sun sensitivity.
  • Tell your provider you take it before any planned surgery.

Related ingredient guides

Citations

  1. Can dong quai help with menopause? healthline.com
  2. Botanical modulation of menopausal symptoms: mechanisms of action pmc.ncbi.nlm.nih.gov

Frequently asked questions

Does dong quai help menopause?

Evidence is limited and mixed. One small trial reported benefits, others did not. It is best discussed with a healthcare provider rather than self-prescribed.

Is dong quai safe with hormone-sensitive conditions?

Probably not. Laboratory studies show weak estrogen-like activity, which makes it a poor fit for conditions like estrogen-receptor positive breast cancer.