Ingredient guide
Forskolin is the active compound in the coleus forskohlii plant, sold for weight loss and testosterone. Human trials are small and mixed, with no reliable weight benefit and only weak, inconsistent hormone effects.
Limited evidenceForskolin is a compound extracted from the root of coleus forskohlii, a plant in the mint family used in traditional medicine. In supplements it is standardised, often to 10 percent forskolin, and marketed mostly for weight loss and, more recently, testosterone.
Forskolin activates an enzyme called adenylate cyclase, which raises a signalling molecule called cyclic AMP inside cells. Cyclic AMP is involved in many processes, including fat breakdown and hormone signalling. On paper that breadth sounds promising, but a compound that touches many pathways at once is hard to translate into a clean human benefit.
For weight, the results are underwhelming. A small study in overweight women found no weight difference versus placebo over 12 weeks, while an older study suggested some favourable change in body composition. Newer work in conjunction with calorie restriction shows modest, inconsistent effects. There is no reliable weight benefit.
For testosterone, one small study reported a rise in free testosterone, and a wider review of herbs for testosterone found only a minority of studies showed a significant effect. We grade the human evidence as limited. Forskolin has interesting biology but little proven, consistent benefit in people.
Products usually provide about 50 mg of forskolin per day from a 10 percent extract. Given the mixed evidence and its blood pressure effects, this is one to approach with realistic expectations and care. Anyone on blood pressure or blood-thinning medicine, or heading for surgery, should check with a healthcare provider first.
Trials often use coleus forskohlii standardised to 10 percent forskolin, providing roughly 50 mg of forskolin per day, for up to 12 weeks. There is no established effective dose. Given mixed results, expectations should stay modest. Ask your healthcare provider before use, especially with blood pressure or blood-thinning medicine.
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The evidence is weak. One small study reported a rise in free testosterone, but most research on herbs for testosterone does not show a consistent effect.
Trials often use a coleus extract standardised to 10 percent forskolin, providing about 50 mg of forskolin per day for up to 12 weeks.
People on blood pressure or blood-thinning medicine, and anyone facing surgery, since it can lower blood pressure and affect bleeding.