Ingredient guide
Lactoferrin is a multifunctional protein found in milk that binds iron and supports immune function. A meta-analysis supports its use in iron deficiency anemia, with greater improvements in iron markers than oral ferrous sulfate. It also modestly supports respiratory health.
Moderate evidenceLactoferrin is a protein found in milk (especially colostrum), tears, saliva, and other body fluids. It is one of the most abundant proteins in breast milk after casein. Its main jobs are binding iron and acting as a frontline immune protein. Supplements use bovine lactoferrin extracted from cow milk.
A meta-analysis of 11 studies in 1,262 participants found that oral lactoferrin gave greater improvements in serum iron, ferritin, and hemoglobin than oral ferrous sulfate, with fewer side effects. A separate systematic review of inflammation, immune function, and respiratory tract infections showed lactoferrin reduced inflammation and modulated immune function. A Cochrane review supports lactoferrin for preventing late-onset sepsis in preterm infants. We grade the evidence as moderate.
Trials commonly use 100 mg to 300 mg of bovine lactoferrin per day for iron deficiency, and up to 600 mg per day for immune use. Take on an empty stomach for best absorption. Ask your healthcare provider before regular use, especially in pregnancy or for children.
A meta-analysis supports better iron, ferritin, and hemoglobin improvements with lactoferrin than oral ferrous sulfate, with fewer side effects.
It has been studied in pregnancy for iron deficiency, often with good tolerability. Still, check with a doctor first.
